Darrell WuDunn, M.D., Ph.D.

Professor of Ophthalmology
Director of Residency Program


Specialty/Research Interests

  • Glaucoma testing
  • Glaucoma surgery
  • Biology of aqueous humor outflow

Education and Training

  • B.S. - University of Chicago, Chicago, Illinois
  • M.D. - University of Chicago, Chicago, Illinois
  • Ph.D. - University of Chicago, Chicago, Illinois
  • Internship - Presbyterian Hospital, Columbia University, New York 
  • Residency - Doheny Eye Institute, University of Southern California, Los Angeles, California
  • Fellowship (Glaucoma) - Bascom Palmer Eye Institute, Miami, Florida

Specialty/Research Interests

  • Glaucoma testing
  • Glaucoma surgery
  • Biology of aqueous humor outflow
Certification/Special Training
  • American Board of Ophthalmology


Dr. WuDunn's IU Health profile


Practice locations

Eugene and Marilyn Glick Eye Institute Ophthalmology Center
1160 West Michigan St.
Indianapolis, IN  46202-5258


Eugene and Marilyn Glick Eye Institute
Spring Mill Medical Building
200 W. 103rd St., Suite 2200
Indianapolis, Indiana 46290




Dr. WuDunn's research covers both the clinical and basic science of ophthalmology, especially relating to glaucoma, with a recent move towards translational research.  Most of the clinical studies have concentrated on outcomes of glaucoma surgery. 

Additionally, Dr. WuDunn is leading a department-wide effort to study proteomics of ocular fluids. The objective is to understand the underlying pathophysiology of major eye diseases by characterizing their proteomic, peptidomic, and metabolomic profiles within ocular fluids and tissues. The aim of this project is to identify protein signaling pathways that are affected in glaucoma and other eye diseases. Our hypothesis is that persons with eye diseases such as glaucoma, cataract and retinopathies have distinctive sets of ocular fluid biomarkers and that a global picture of the proteins and peptides present in diseased ocular fluid will provide new insight into disease processes and pathology. These pathways could then serve as potential new targets for therapy.

To achieve our goal, Dr. WuDunn has been collaborating with proteomic and statistically investigators at Indiana University with prior experience in proteomic biomarker studies. Initial concerntrations have been on comprehensive  protein, peptide, and metabolite characterization via global analysis of aqueous and vitreous humor by mass spectrometry, NMR spectrometry, and protein antibody arrays. By utilizing the software application and analysis workflow, the team will integrate this molecular profiling with hypothesis-driven research to better understand the targeted eye diseases. This synergy between traditional hypothesis-driven research and “integromics”-era molecular profiling will serve as the springboard for further funding opportunities.


Professional Service and Memberships

1990-      Association for Research in Vision and Ophthalmology

1993-      American Academy of Ophthalmology (AAO)

1995-      Indiana Academy of Ophthalmology

1998-      American Glaucoma Society

2007-      AAO Glaucoma committee, Ophthalmic News and Education Network

2007-      Associate member, Association of University Professors of Ophthalmology

2007-      Scientific Grants Review Committee, BrightFocus Foundation
                    (formerly America Health Assistance Foundation) – Glaucoma Research

2008-      Senior Editor, Glaucoma section, Ophthalmic News and Education (O.N.E.)
                     Network, AAO
2012-      Finance Committee, American Glaucoma Society

2012-      Research Committee, American Glaucoma Society



2002, 2008      Professor of the Year, Indiana University Dept. of Ophthalmology

2006               Achievement Award, American Academy of Ophthalmology

2007-              Best Doctors in America

2008 & 2010    Secretariat Award, American Academy of Ophthalmology

1160 W. Michigan St. | Indianapolis, IN 46202 | Ph: (317) 944-2020