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Lyne Racette, Ph.D.

Assistant Professor of Ophthalmology


 

My research focuses on detecting and monitoring glaucoma progression. While the presence and rate of glaucoma progression influences treatment decisions, the methods currently available to detect and monitor progression are imprecise and do not allow clinicians to make accurate assessments of the status of their patients. A second research area targets health disparities in glaucoma. We are currently developing new approaches to improve adherence to the medical treatment of glaucoma in patients of African descent. 

CURRENT GRANTS

Glaucoma Research Foundation Shaffer Grant
Role: Principle Investigator
Title: Early detection of glaucoma progressions using structural data jointly
Description: The long-term goal of this project is to detect glaucoma progression in the early stage of the disease using structural and functional data jointly. The goal of this project is to assess the sensitivity and specificity of the Dynamic Structure-Function model to detect conversion from ocular hypertension to primary open-angle glaucoma.

Prevent Blindness America Investigator Award
Role: Principal Investigator
Title
: The effectiveness of motivational interviewing to improve adherence to glaucoma treatment in patients of African descent.
Description
: People of African descent are disproportionately affected by primary open-angle glaucoma, a potentially blinding disease. This high-risk population is also less likely to adhere to the sight-preserving medical treatment of glaucoma. We propose to use motivational interviewing, an approach shown to be particularly effective to improve adherence to treatment in minority populations in other chronic diseases, to improve adherence to glaucoma treatment in people of African descent.

BrightFocus Foundation
Role: Principal Investigator
Title: An individualized model to monitor glaucoma progressio
Description: The objective of this project is to validate a dynamic structure-function model developed to monitor the progression of glaucoma. The model estimates the current state of the disease using centroids and estimates the trend of change using velocity vectors. Our first specific aim is to validate this model in the Ocular Hypertension Treatment Study Cohort (OHTS). Our second specific aim is to estimate the sensitivity and specificity of the dynamic structure-function model.

IUPUI DRIVE  
Role: Principal Investigator 
Title: A novel individualized structure-function model to monitor glaucoma progression
Description: The objective of this project is to develop a novel framework to improve the detection of glaucoma progression. The model we propose will be individualized to each patient and will use both structural and functional data.

IUPUI Multidisciplinary Undergraduate Research Institute
Role: Principal Mentor
Title: Improving adherence to glaucoma treatment in patients of African Descent by combining an educational intervention with motivational interviewing
Description
: The objective of this mentoring award is to provide a research learning opportunity to four undergraduate students and to improve adherence to the medical treatment of glaucoma in patients of African descent.

Research to Prevent Blindness

Title: A psychophysical investigation of cortical deficits in glaucoma
Role: Principal Investigator
Description
: The goal of this project is to use psychophysical methods to identify the presence of cortical deficits in glaucoma.


COMPLETED RESEARCH GRANTS

Indiana CTSI PDT grant
Title: A novel approach to improve compliance for amblyopia treatment in children
Role: Co-Principal Investigator
Principal investigators: Jingyun Wang and Lyne Racette
Description: The major goal of this project will to apply a novel approach to improve compliance of atropine amblyopia treatment.

UCSD Health Sciences Academic Senate
Title: Concurrent age-related macular degeneration and primary open-angle glaucoma 
Role: Principal Investigator
Description: In the developed world, age-related macular degeneration (ARMD) and primary open-angle glaucoma (POAG) are two of the leading causes of visual impairment and blindness. ARMD affects central vision while POAG affects peripheral vision. These two age-related diseases can occur concurrently and when they do, they have a devastating impact on vision. This pilot research project was a first step towards determining whether the structural changes observed in patients with concurrent ARMD and POAG are worse than those observed in patients with ARMD-alone and with POAG-alone

 

IU Health Values Fund for Research
Title: Structural changes in the eye of patients with concurrent macular degeneration and glaucoma
Role: Co-investigator
Principal investigator: Anh-Danh Phan
Description: In the developed world, age-related macular degeneration (ARMD) and primary open-angle glaucoma (POAG) are two of the leading causes of visual impairment and blindness. ARMD affects central vision while POAG affects peripheral vision. These two age-related diseases can occur concurrently and when they do, they have a devastating impact on vision. With the imminent aging of the population, it is expected that over 1.8 million Americans over the age of 70 will be affected by concurrent ARMD and POAG by the year 2030. It is challenging to monitor these patients since there is no standardized practice pattern for interpreting the significance of conventional diagnostic tests results. Patients with concurrent ARMD and POAG may therefore not be adequately treated. This research project will determine whether the structural changes observed in patients with concurrent ARMD and POAG are worse than those observed in patients with ARMD-alone and with POAG-alone. The long-term goal of this project is to improve the treatment and visual outcome of patients with concurrent ARMD and POAG.

 

Indiana University Biomedical Research Grant
(still active through a one-year extension at no cost)
Title: Racial differences in visual function and retinal blood flow in healthy eyes
Role: Principal Investigator
Description: People of African descent (AD) are disproportionately affected by primary open-angle glaucoma (POAG). Compared to people of European descent (ED), the prevalence of POAG in people of AD is up to six times higher in certain age groups. The disease appears approximately ten years earlier, progresses faster and does not respond as well to treatment in people of AD. The underlying causes of this health disparity are not well understood. The long-term objective of the present study is to understand racial differences in visual function and how these differences may be the result of a dysregulation of the ocular blood flow system.

 

Indiana University EMPOWER grant
Role: Principal Investigator
Description: Through this mentoring grant, I was matched with Mary Austrom, an experienced mentor and researcher in the Department of Psychiatry. I chose to be matched with someone outside my own Department because I already have outstanding mentors within my area of research. I wanted to learn from the experience of someone with a different perspective. Also, one of the goals of this award was to prepare to apply for external funding: working with someone who is highly experienced yet unfamiliar with my research topic gave me the advantage of improving the clarity of my writing.

 

NEI (NIH)
Title: African and European descent, ocular blood flow and glaucoma progression
Role: Co-investigator
Principal investigator: Alon Harris
Description: The objective of this study is to explore the role of vascular risk factors in explaining the mechanisms behind the disparity of glaucoma in persons of African descent compared to those of European descent. The known increased prevalence of systemic vascular disease in the African descent population suggests that deficiencies in ocular perfusion pressure and blood flow may have a significant role in explaining these inequalities. Our unique secondary analysis of the Indianapolis Glaucoma Progression Study data which includes comprehensive ocular perfusion pressure, blood flow, retinal and optic nerve structure, visual function and their relationship to disease progression has the potential to elucidate, for the first time, the reason for the disparity in glaucomatous disease between those of African descent and European descent.

 

IUPUI Multidisciplinary Undergraduate Research Institute
Role
: Principal Mentor
Title
: The effectiveness of motivational interviewing to improve adherence to glaucoma treatment in    patients of African descent
Description
: The objective of this mentoring award is to provide a research learning opportunity to four undergraduate students and to improve adherence to the medical treatment of glaucoma in patients of African descent.

 

Indiana University Collaborative Research Grant
Title: A Novel Retinal Imaging Approach to Diagnose Glaucoma
Role: Principal investigator
Description: Glaucoma detection and monitoring is currently achieved through a combination of clinical, functional and structural assessment. Each of these has its strength and weaknesses. In this proposal, we focus on the assessment of the retinal nerve fiber layer using spectral-domain optical coherence tomography. The goal of the project is to develop a novel algorithm that capitalizes on the anatomical distribution of the fibers to improve the sensitivity and specificity of glaucoma detection and progression.

 


 

SELECTED PUBLICATIONS  
see also Dr. Racette's publications as indexed in

 

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Khanal S, Davey PG, Racette L, Thapa M. Intraeye retinal nerve fiber layer and
macular thickness asymmetry measurements for the discrimination of primary
open-angle glaucoma and normal tension glaucoma. J Optom. 2015 Nov 30. pii:
S1888-4296(15)00081-3. doi: 10.1016/j.optom.2015.10.002. [Epub ahead of print]
PubMed PMID: 26652244.
 

Hu R, Marín-Franch I, Racette L. Prediction accuracy of a novel dynamic structure-function model for glaucoma progression. Invest Ophthalmol Vis Sci,  2014 Oct 30;55(12):8086-94.

Khanal S, Thapa M, Racette L, Johnson R, Davey PG, Joshi MR, Shrestha GS. Retinal nerve fiber layer thickness in glaucomatous Nepalese eyes and its relation with visual field sensitivity. J Optom, 7(4), 217-224.

Siesky B, Harris A, Racette L, Abassi R, Chandrasekhar K, Tobe LA, Behzadi J, Eckert G, Amireskandari A, Muchnik M. Differences in ocular blood flow in glaucoma between patients of African and European descent. J Glaucoma, June 25, Epub ahead of print. PMID: 23807346

Ng M, Sample PA, Pascual JP, Zangwill LM, Girkin CA, Liebmann JM, Weinreb RN, Racette L. Comparison of visual field severity classification systems for glaucoma. J Glaucoma, 21(8), 551-61. 2012. PMCID: PMC3246042

Racette L, Liebmann JM, Girkin CA, Zangwill LM, Jain S, Becerra LM, Medeiros FA, Bowd C, Weinreb RN, Boden C, Sample PA; for the ADAGES study group. African Descent and Glaucoma Evaluation Study (ADAGES). III. Ancestry differences in visual function in healthy eyes. Arch Ophthalmol, 128(5), 551-559, 2010. PMCID: PMC2907156

Girkin CA, Sample PA, Liebmann JM, Jain S, Bowd C, Becerra LM, Medeiros FA, Racette L, Dirkes KA, Weinreb RN, Zangwill LM; for the ADAGES study group. African Descent and Glaucoma Evaluation Study (ADAGES). II. Ancestry differences in optic disc, retinal nerve fiber layer, and macular structure in healthy subjects. Arch Ophthalmol, 128(5), 541-550, 2010. PMCID: PMC2910255

Racette L, Chiou CY, Hao JC, Bowd C, Goldbaum MH, Zangwill LM, Lee TW, Weinreb RN, Sample PA. Combining functional and structural tests improves the diagnostic accuracy of relevance vector machine classifiers. J Glaucoma, 19(3), 167-175, 2010. PMCID: PMC2891254

Racette L, Casson PR, Claman P, Zackon DH, Casson EJ. An investigation of the visual disturbances experienced by patients on clomiphene citrate. Fertil Steril, 93(4), 1169-1172, 2010. PMID: 19135656

Tafreshi A, Racette L, Weinreb RN, Sample PA, Zangwill LM, Medeiros FA, Bowd C. Pattern electroretinogram and psychophysical tests of visual function for discriminating between healthy and glaucoma eyes. Am J Ophthalmol, 149(3), 488-495, 2010. PMCID: PMC2827352

Sample PA, Girkin CA, Zangwill LM, Jain S, Racette L, Becerra LM, Weinreb RN, Medeiros FA, Wilson MR, De León-Ortega J, Tello C, Bowd C, Liebmann JM; African Descent and Glaucoma Evaluation Study Group. The African Descent and Glaucoma Evaluation Study (ADAGES): Design and Baseline Data. Arch Ophthalmol, 127(9), 1136-1145, 2009. PMCID: PMC2761830

Ng M, Racette L, Pascual JP, Liebmann JM, Girkin CA, Lovell SL, Zangwill LM, Weinreb RN, Sample PA. Comparing the full-threshold and Swedish Interactive Thresholding Algorithm for short-wavelength automated perimetry. Invest Ophthalmol Vis Sci, 50(4), 1726-1733, 2009. PMCID: PMC2716113

Tafreshi A, Sample PA, Liebmann JM, Girkin CA, Zangwill LM, Weinreb RN, Lalezary M, Racette L. Visual function-specific perimetry to identify glaucomatous visual loss using three different definitions of visual field abnormality. Invest Ophthalmol Vis Sci, 50(3), 1234-1240, 2009. PMCID: PMC2848160

Racette L, Medeiros FA, Zangwill LM, Ng D, Weinreb RN, Sample PA. Diagnostic accuracy of the Matrix 24-2 and original N-30 Frequency-Doubling Technology tests compared with Standard Automated Perimetry..Invest Ophthalmol Vis Sci, 49(3), 954-960, 2008. PMCID: PMC2367320

Racette L, Medeiros FA, Bowd C, Zangwill LM, Weinreb RN, Sample PA. The impact of the perimetric measurement scale, sample composition, and statistical method on the structure-function relationship in glaucoma. J Glaucoma, 16(8), 676-684, 2007. PMID: 18091454

Zangwill LM, Jain S, Racette L, Ernstrom KB, Bowd C, Medeiros FA, Sample PA, Weinreb RN. The effect of disc size and severity of disease on the diagnostic accuracy of the Heidelberg retina tomograph glaucoma probability score. Invest Ophthalmol Vis Sci, 48(6), 2653-2660, 2007. PMID: 17525196

Ng D, Zangwill LM, Racette L, Bowd C, Pascual JP, Bourne RRA, Boden C, Weinreb RN, Sample PA. Agreement and repeatability for standard automated perimetry and confocal scanning laser ophthalmoscopy in the Diagnostic Innovations in Glaucoma Study. Am J Ophthalmol, 142(3), 381-386, 2006. PMID: 16935580

Sample PA, Medeiros FA, Racette L, Pascual JP, Boden C, Zangwill LM, Bowd C, Weinreb RN. Identifying glaucomatous vision loss with visual-function-specific perimetry in the Diagnostic Innovations in Glaucoma Study. Invest Ophthalmol Vis Sci, 47(8), 3381-3389, 2006. PMID: 16877406

Racette L, Boden C, Kleinhandler SL, Girkin CA, Liebmann JM, Zangwill LM, Medeiros FA, Bowd C, Weinreb RN, Wilson MR, Sample PA. Differences in visual function and optic nerve structure between healthy eyes of blacks and whites. Arch Ophthalmol, 123(11), 1547-1553, 2005. PMID: 16286617

Racette L, Casson EJ. The impact of visual field loss on driving performance: evidence from on-road driving assessments. Optom Vis Sci, 82(8), 668-674, 2005. PMID: 16127331

Daneshvar H, Racette L, Coupland SG, Kertes PJ, Guberman A, Zackon D. Symptomatic and asymptomatic visual loss in patients taking vigabatrin. Ophthalmology, 106(9), 1792-98, 1999. PMID: 10485552

Zackon DH, Casson EJ, Zafar A, Stelmach L, Racette L. The temporal order judgment paradigm: subcortical attentional contribution under exogenous and endogenous cueing conditions. Neuropsychologia, 37(5), 511-520, 1999. PMID: 10340311

Zackon DH, Casson EJ, Stelmach L, Faubert J, Racette L. Distinguishing subcortical and cortical influences in visual attention. Invest Ophthalmol Vis Sci, 38(2), 364-371, 1997. PMID: 9040469

von Grünau M, Racette L, Kwas M. Measuring the attentional speed-up in the motion induction effect. Vision Res, 36(16), 2433-2446, 1996. PMID: 8917806


Other publications

Conference proceedings

Casson E, Racette L. Comprehensive survey of vision standards for driving, vision assessment and appeal procedures in Canada and the United States. Conference Proceedings of the 8th International Conference on Vision in Vehicles, Gale AG, Brown ID, Haselgrave CM, Taylor SP (Eds), Loughborough University, Leicestershire, UK, 3-10, 2012.

Book chapter

Racette L, Sample PA. Short-wavelength automated perimetry. Sample PA, Girkin CA (Guest Eds), W.B. Saunders Company (a division of Elsevier), Philadelphia, Ophthalmol Clin North Am, 16(2), 227-236, 2003. PMID: 12809160

 

 

Degrees Awarded

  • B.A.  - Concordia University, Montreal, Canada
  • M.A. - Carleton University, Ottawa, Canada
  • Ph.D. - Carleton University, Ottawa, Canada

Postdoctoral

  • Research fellowship in Ophthalmology - University of California at San Diego, CA

Professional honors & awards

  • IUPUI Student Supervisor of the Year - 2013

Lab staff and students

 

 
Postdoctoral Fellow
   
racette_lab.jpg  

 

Fang-I Chu
Ph.D. - Statistics & applied probability, University of California, Santa Barbara

Research Fellows    
ramesani-6.jpg   Koosha Ramezani
M.D. - Shahid Beheshi University of Medical Sciences, Tehran Iran
 Students  
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Casey Bauchle
Undergraduate in psychology and neurosciences with minors in chemistry and computer science - IUPUI
m-benjamin.jpg
  Mercy Benjamin
Undergraduate in Business Management/Human Resource Management, Indiana University Purdue University, Indianapolis
Diallo_racette-lab.jpg   Kadé Diallo
Purdue School of Engineering & Technology, IUPUI

Bachelor of Science in Biomedical Engineering
Minor in Physics
 McIntyre_racette-lab.jpg   Elizabeth McIntyre
Purdue School of Science, IUPUI

Bachelor of Science in Neuroscience
Lab Alumni - Graduates & Postgraduates
 R-3.jpg  

Rongrong Hu
M.D. - Zhejiang University School of Medicine, China

Research fellowship (2012-14)
Current location: Dept. of Ophthalmology, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China

Idowu-racette-lab.jpg   Eniola Idowu
School of Science,
Indiana University Purdue Universisty, Indianapolis,

Bachelor of Science, Chemistry

Lab alumni - Undergraduates
Shelbi Grow
Undergraduate in Biology at IUPUI.   Starting Masters in Anatomy at IU School of Medicine, Fall, 2015.
   
  • Association for Research in Vision and Ophthalmology (ARVO) - 2005 - present
    (Chair-elect: ARVO Diversity Issues Committee - 2015)
  • North-American Perimetric Society (NAPS) - 2005 - present
  • Imaging and Perimetry Society (IPS) - formerly the Internaional Perimetric Society - 2008 - present
  • Optometric Glaucoma Society (OGS) - 2009 - present
  • International Society for Eye Research (ISER) - 2011 - present
  • Group on Women in Medicine and Science (GWIMS) - 2013 - present

Academic editing and reviewing

  • Investigative Ophthalmology and Visual Science
  • Optometry and Vision Science
  • British Journal of Ophthalmology  
  • Journal of Glaucoma  
  • Ophthalmologica     
  • Medical Care      
  • Acta Ophthalmologica Scandinavia 
  • Archives of Ophthalmology     
  • Clinical Ophthalmology             
  • American Journal of Ophthalmology   
  • Ophthalmic Surgery, Lasers and Imaging    
  • The Open Ophthalmology Journal               
  • Current Eye Research      
  • Eye
  • BioMed Research International             
  • Vision Research
  • Ophthalmic Physiological Optics       
  • Epidemiology Research International   
  • Journal of Ophthalmology                  

1160 W. Michigan St. | Indianapolis, IN 46202 | Ph: (317) 944-2020